Publications Archive - Domain Therapeutics North America

Publications

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Find below reference publications demonstrating various applications of our biosensors, and the importance of GPCR signaling profiling

G protein-coupled receptor (GPCR) pharmacogenomics

Know your molecule: pharmacological characterization of drug candidates to enhance efficacy and...

EGFR signaling and pharmacology in oncology revealed with innovative BRET-based biosensors

January 8, 2024

Functional selectivity of Receptor Tyrosine Kinases regulates distinct cellular outputs

Chronic UCN2 treatment desensitizes CRHR2 and improves insulin sensitivity

A systematic analysis of prostaglandin E 2 type 3 receptor isoform signaling reveals isoform- a...

Common coupling map advances GPCR-G protein selectivity

Effector membrane translocation biosensors reveal G protein and βarrestin coupling profiles of...

August 25, 2021

Mechanistic insights into dopaminergic and serotonergic neurotransmission – concerted interac...

September 9, 2019

Exploring use of unsupervised clustering to associate signaling profiles of GPCR ligands to cli...